Background: E-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. Loss of the adhesive function of E-cadherin seems to promote invasive and metastatic properties of neoplastic cells. Objectives: The present study is a retrospective study aiming to evaluate the loss of E-cadher...

background : e-cadherin is a trans-membrane glycoprotein that plays a critical role in many aspects of cell adhesion as well as establishment and maintenance of epithelial cell polarity. loss of the adhesive function of e-cadherin seems to promote invasive and metastatic properties of neoplastic cells.   objectives: the present study is a retrospective study aiming to evaluate the loss of e-cad...

background: proliferating cell nuclear antigen (pcna) is a nuclear protein synthesized in the late g1 and s-phase of the cell cycle. detection of this protein represents a useful marker of the proliferation status of lesions. this study has been carried out to evaluate the cell proliferation rate in oral lichen planus (olp) and comparison between plaque and erosive lichen planus, which indicate...

Background & Aims: The role of P53 and proliferating cell nuclear antigen (PCNA) genes in inflamed and non-inflamed odontogenic cysts is related to cell proliferation but it is unclear. The aim of this study was immunohistochemical evaluation of P53 and PCNA expression in inflamed and non-inflamed dentigerous cysts Methods: In the present study, 23 dentigerous cysts (12 inflamed and 11 non-infl...

The purpose of this study was to explore the correlations arterial-phase enhanced CT characteristics hepatocellular carcinoma (HCC) with differentiation degree and expressions proliferating cell nuclear antigen (PCNA) phosphatase tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced before surgery were selected observe characteristics. tissue eva...

This study investigated how Michauxia campanuloides affects the Proliferating Cell Nuclear Antigen (PCNA) expression in granulosa cells, ovarian histomorphology and serum total antioxidant capacity (TAC) rats. Rats were divided into control (C), treatment 1 (T 1) 2 2) groups. The rats T groups received aqueous extract of M. at doses 20 mg/kg/day 40 orally for 21 days, respectively. Serum TAC le...

conclusions w. coagulans inhibits the development of bph can be useful for the treatment of this condition. results the present study revealed that bph caused elevation of mda levels, suppression of tac levels, and increased pcna expression in the prostate gland. interestingly, in a dose-dependent manner, wce caused decreased mda levels and increased tac levels in the prostate gland, compared t...

We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.